Centre For Drug Candidate Optimisation (CDCO)



Centre for Drug Candidate Optimisation
Monash Institute of Pharmaceutical Sciences
Monash University (Parkville campus)
381 Royal Parade
Parkville Victoria 3052 Australia

Phone: +61 3 9903 9626 or +61 3 9903 9149

Email:  Professor Susan Charman, Director susan.charman@monash.edu

The Centre for Drug Candidate Optimisation (CDCO) is a unique not-for-profit venture based within Monash University's Institute of Pharmaceutical Sciences (MIPS) that provides collaborative ADME lead candidate optimisation expertise and infrastructure to support emerging drug discovery programs. Drug candidate optimisation fills a crucial gap between discovery and development by integrating pharmacokinetic properties into medicinal chemistry and biology programs to provide a rational means of identifying drug candidates suitable for progression into preclinical and clinical development. This process has become an essential, value-creating component of modern drug discovery.

The CDCO’s expertise encompasses the disciplines of physical and preformulation chemistry, pharmacokinetics, drug metabolism and bioanalysis to provide the necessary platforms for rapid identification of developmental properties.

Core areas of expertise:

  • Physicochemical profiling
  • Drug permeability
  • Drug metabolism and metabolite profiling
  • Metabolic drug-drug interactions
  • Bioavailability and pharmacokinetics
  • Preclinical formulation development
  • Solid state characterisation and salt selection
  • Stability testing and impurity profiling
  • Quantitative bioanalysis

The CDCO undertakes its research to industry standards and can implement rapid and flexible study design to suit the needs of individual drug discovery programs.